305 - Tubal primary metastatic choriocarcinoma coexistent with a viable early pregnancy: a case report
305 - Tubal primary metastatic choriocarcinoma coexistent with a viable early pregnancy: a case report
Stefano Cianci(1), Salvatore Giovanni Vitale(1), Roberto Tozzi(2), Pietro Cignini(3), Francesca Padula(3), Laura D’Emidio(3), Lucia Magnifico(3), Claudio Giorlandino(3), Luigi Frigerio(4), Diego Rossetti(4), Salvatore Caruso(1)
Abstract: Introduction Fallopian tube choriocarcinoma coexistent with viable intrauterine pregnancy i san extremely rare condition.
Case Report: we present the first case reported in literature of tubal choriocarcinoma coexistent with viable intrauterine pregnancy detected at early gestional age (20 weeks) and successfully managed by seriate monitoring of maternal and fetal health status until 31 weeks, then treated by cesarean section followed by etoposide, methotrexate, acttinomycin D, cyclophosphamide, and vincristine(EMA-CO) chemotherapy protocol.
Conclusions: the outcome was favorable for both the mother and her fetus.
Intreoduction: Choriocarcinoma is a rare variant of gestional trophoblastic disease. This is a high malignant neoplasia composed by cyto-and syncizitrophoblaastic tissue characterized by atypical and irregular cells proliferation that cause necrosis(1). The incidence of choriocarcinoma is estimated to be 0.133 per 100.000 woman-years and the incidence with a concomitant normal pregnancy is a case per 160.000 pregnancies(2)
